LASSI-L intrusion errors distinguish plasma p-tau217 status
LASSI-L intrusion errors distinguish plasma p-tau217 status
Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217− after adjusting for initial learning strength
Curiel Cid et al., Frontiers in Neurology (2025)
LASSI-L intrusion errors distinguish plasma p-tau217 status
Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tau217+ from p-tau217− after adjusting for initial learning strength
SUMMARY
The investigators studied 158 older adults who completed the LASSI-L, including 108 people with amnestic mild cognitive impairment. Within the aMCI group, 58 were plasma p-tau217 positive and 50 were below the positivity threshold. The analysis focused on semantic intrusion errors produced while learning a competing word list and, importantly, adjusted for age, global cognition, and each participant’s maximum learning capacity on the initial list.
Even after accounting for initial learning strength, the p-tau217-positive aMCI group made more semantic intrusion errors on both competing-list trials. Older age, APOE ε4 status, and higher p-tau217 also predicted elevated intrusion errors. The LASSI-L therefore supplied cognitive evidence that was closely aligned with biological Alzheimer’s disease risk but not reducible to a general inability to learn. Its structured interference paradigm helps reveal problems with inhibition, source memory, and self-monitoring that can sharpen interpretation of a positive blood biomarker.
