At i-Function®, we believe better brain health means better quality of life. Our mission is to empower healthcare professionals and end users with tools that detect, monitor, and strengthen cognitive and functional skills functions.

Early detection of amnestic mild cognitive impairment (aMCI) is crucial for early intervention. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) identify risk for cognitive decline by measuring proactive semantic interference (PSI). PSI correlates with critical Alzheimer’s disease (AD) biomarkers, predicting decline. A digital version of the LASSI™, the LASSI-D™, was highly convergent with the LASSI-L in older participants. We developed three alternative forms of the LASSI-D™, examining convergence across forms and retest changes, to evaluate utility as a repeated-measure

The three digital alternative forms of the LASSI™ (LASSI-D™) were highly convergent with each other and the LASSI-L. The findings provide evidence of the utility of a cloud-based, self-administered cognitive challenge test with alternative forms.

This study reports on the development and initial validation of a self-administered computerized version of the Loewenstein-Acevedo Scales for Semantic Interference (LASSI), the digital LASSI (LASSI-D). A self-administered digital version, with an artificial intelligence–generated avatar assistant, was the migrated assessment.

The results for the digital migration of the LASSI-D were highly convergent with the legacy LASSI-L. Across all indices of similarity, including sensitivity, criterion validity, classification accuracy, and performance, the versions converged across languages. The current data provide convincing evidence of the use of a fully self-administered digitally migrated cognitive challenge test.

Huntington’s disease (HD) is characterized by progressive cognitive decline, with early deficits often preceding motor symptoms. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) captures many types of deficits in verbal memory including susceptibility to interference. The current study aims to delineate the progression of these deficits across different stages of HD.

The LASSI-L appears to be a useful tool for detecting early and progressive cognitive changes in Huntington’s disease, particularly by capturing the sequential nature of verbal memory deficits, including early vulnerability to interference. These findings suggest that the LASSI-L may help refine HD staging by integrating sequential neuropsychological markers of cognitive decline.

Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by Aβ load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test.

Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.